1.0The Medical Xchangehttps://themedicalxchange.com/en/Chapter 4: Neurocognitive Deficit - The Medical Xchangerich600338<blockquote class="wp-embedded-content" data-secret="uNKlqWijLH"><a href="https://themedicalxchange.com/en/review/the-aging-hiv-patient-2/">Chapter 4: Neurocognitive Deficit</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://themedicalxchange.com/en/review/the-aging-hiv-patient-2/embed/#?secret=uNKlqWijLH" width="600" height="338" title="“Chapter 4: Neurocognitive Deficit” — The Medical Xchange" data-secret="uNKlqWijLH" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script type="text/javascript">
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https://themedicalxchange.com/wp-content/uploads/2011/12/HIV_Clinical_Summary_slides_EN.png960720Cognitive decline is an insidious and frequently progressive complication of human immunodeficiency virus (HIV) infection. While the introduction of highly active antiretroviral therapy (HAART) largely eliminated the dementia associated with end-stage acquired immunodeficiency syndrome (AIDS), cognitive impairment remains a common complication of HIV even in those with well controlled viremia. The incidence and the severity of HIV-associated neurocognitive disorders (HAND) are rising with an aging HIV population – a potential consequence of both increased susceptibility in older individuals and progressive impairment with longer duration of infection. The clinical challenges posed by this complication are substantial. The relative ability of specific antiretroviral therapies to cross the blood brain barrier to reduce central nervous system (CNS) viral load, and the specific, perhaps genetic, susceptibility of individual patients are among factors that may explain the variable risk of cognitive impairment. In addition, HIV-independent variables may also be important in some individuals. Clinical sensitivity to changes in cognitive function through periodic assessments is appropriate in the context of strategies to understand and prevent HAND.