{"version":"1.0","provider_name":"The Medical Xchange","provider_url":"https:\/\/themedicalxchange.com\/en\/","title":"Randomized Comparison Distinguishes PPIs for Relative Effect on Antiplatelet Agent Activity - The Medical Xchange","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"RhMds6rSKL\"><a href=\"https:\/\/themedicalxchange.com\/en\/2011\/04\/02\/american-college-of-cardiology-acc-60th-annual-sci\/\">Randomized Comparison Distinguishes PPIs for Relative Effect on Antiplatelet Agent Activity<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/themedicalxchange.com\/en\/2011\/04\/02\/american-college-of-cardiology-acc-60th-annual-sci\/embed\/#?secret=RhMds6rSKL\" width=\"600\" height=\"338\" title=\"&#8220;Randomized Comparison Distinguishes PPIs for Relative Effect on Antiplatelet Agent Activity&#8221; &#8212; The Medical Xchange\" data-secret=\"RhMds6rSKL\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/themedicalxchange.com\/wp-includes\/js\/wp-embed.min.js\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2011\/04\/ACC_EN_Figure_1.jpg","thumbnail_width":2200,"thumbnail_height":1650,"description":"New Orleans \u2013 Some proton pump inhibitors (PPIs) may pose a substantial risk of drug-drug interactions by competing for metabolism through the hepatic cytochrome P450 system. One of the most serious potential interactions is with clopidogrel, an antiplatelet agent that prevents cardiovascular (CV) events. However, a recent randomized comparison of PPIs, not all of which are dependent on hepatic metabolism, demonstrated important relative differences for a clopidogrel interaction. Of PPIs studied on standard dosing, a new agent in this class produced the least antiplatelet impairment, while an older agent produced the most. The findings are relevant to the potentially life-saving effects of clopidogrel in the context of PPIs, which are commonly co-administrated in the many patients with CV disease who need gastroprotection. This comparative study also supplied insight on the heterogeneous pharmacokinetics of clopidogrel, which ranged broadly among subjects even prior to PPI administration."}