{"version":"1.0","provider_name":"The Medical Xchange","provider_url":"https:\/\/themedicalxchange.com\/en\/","title":"Fixed-Dose Combinations: Comparing Similar Strategies when Degree of Blood Pressure Lowering is Important - The Medical Xchange","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"5QAN3rEwJj\"><a href=\"https:\/\/themedicalxchange.com\/en\/2011\/05\/21\/american-society-of-hypertension-ash-26th-annual-2\/\">Fixed-Dose Combinations: Comparing Similar Strategies when Degree of Blood Pressure Lowering is Important<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/themedicalxchange.com\/en\/2011\/05\/21\/american-society-of-hypertension-ash-26th-annual-2\/embed\/#?secret=5QAN3rEwJj\" width=\"600\" height=\"338\" title=\"&#8220;Fixed-Dose Combinations: Comparing Similar Strategies when Degree of Blood Pressure Lowering is Important&#8221; &#8212; The Medical Xchange\" data-secret=\"5QAN3rEwJj\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/themedicalxchange.com\/wp-includes\/js\/wp-embed.min.js\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2011\/05\/ASH_Figure_1__.JPG","thumbnail_width":960,"thumbnail_height":720,"description":"New York \u2013 Due to the frequency with which hypertensive patients require more than one therapy to reach treatment goals, fixed-dose drug combinations have been widely embraced for convenience, but the efficacy of single-pill combinations are not necessarily comparable even when the component drug classes are the same. In a double-blind study conducted with a new angiotensin receptor blocker (ARB), a single-pill fixed-dose combination with a diuretic was more effective for reducing both clinic and ambulatory blood pressures than a similar coupling of agents from the same classes. The fixed-dose trial is consistent with a series of studies conducted previously with the same ARB, indicating that the features of this agent are unique relative to earlier generation drugs from the same class. The greater likelihood of reaching therapeutic targets has major implications for reducing the risk of cardiovascular events."}