{"version":"1.0","provider_name":"The Medical Xchange","provider_url":"https:\/\/themedicalxchange.com\/en\/","title":"Simplified Dosing with Single-pill Combinations: Focus on Blood Pressure Goals - The Medical Xchange","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"mPhHFB7ji2\"><a href=\"https:\/\/themedicalxchange.com\/en\/2011\/10\/02\/2011-canadian-hypertension-congress\/\">Simplified Dosing with Single-pill Combinations: Focus on Blood Pressure Goals<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/themedicalxchange.com\/en\/2011\/10\/02\/2011-canadian-hypertension-congress\/embed\/#?secret=mPhHFB7ji2\" width=\"600\" height=\"338\" title=\"&#8220;Simplified Dosing with Single-pill Combinations: Focus on Blood Pressure Goals&#8221; &#8212; The Medical Xchange\" data-secret=\"mPhHFB7ji2\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/themedicalxchange.com\/wp-includes\/js\/wp-embed.min.js\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2011\/10\/CHC_EN_Figure_1.PNG","thumbnail_width":960,"thumbnail_height":720,"description":"Alliston \u2013 More than two thirds of patients with hypertension require two or more antihypertensive agents to achieve blood pressure (BP) goals. Combination therapy is so fundamental to effective BP control that the most recent Joint National Committee guidelines (JNC 7) recommend considering combination therapy as an initial strategy when BP is >20\/10 mmHg above goal. To reduce complexity, there are now a variety of single-pill combinations, often suitable for once-daily dosing, to allow goals to be achieved and sustained with minimal demands of the patient and physician. While many of these combinations include a renin-angiotensin system (RAS) inhibitor because of favourable effects on multiple organ systems beyond the vasculature, including renal function and anti-hypertrophic effects on cardiac tissue, the key question has been which RAS inhibitor to use combined with which second agent."}