{"version":"1.0","provider_name":"The Medical Xchange","provider_url":"https:\/\/themedicalxchange.com\/en\/","title":"Bile Acid Sequestrants: Putting a Unique Mechanism to Work - The Medical Xchange","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"YJH0Zj8OHY\"><a href=\"https:\/\/themedicalxchange.com\/en\/review\/bile-acid-sequestrants-putting-a-unique-mechanism\/\">Bile Acid Sequestrants: Putting a Unique Mechanism to Work<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/themedicalxchange.com\/en\/review\/bile-acid-sequestrants-putting-a-unique-mechanism\/embed\/#?secret=YJH0Zj8OHY\" width=\"600\" height=\"338\" title=\"&#8220;Bile Acid Sequestrants: Putting a Unique Mechanism to Work&#8221; &#8212; The Medical Xchange\" data-secret=\"YJH0Zj8OHY\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/themedicalxchange.com\/wp-includes\/js\/wp-embed.min.js\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2012\/03\/XR_3003_ExpertReport_EN_Fig_1.PNG","thumbnail_width":960,"thumbnail_height":720,"description":"Bile acid sequestrants were initially developed for the treatment of hypercholesterolemia, but it is significant that essentially all the activity of these agents is confined to the gastrointestinal (GI) tract. The binding of bile acid in the intestine inhibits a key mechanism of cholesterol transport, but the GI applications of these agents are also considerable. Over the last decade, as statins have become the dominant treatment for elevated low density lipoprotein (LDL) cholesterol, GI applications have grown in relative importance. Although drugs in this class have been available for 50 years, the broad clinical applications deserve to be revisited. There has been a recent resurgence in the use of bile acid sequestrants for cardiovascular protection due to the intolerability of the very high doses of statins, but these agents are also relevant for use with several GI disorders."}