{"version":"1.0","provider_name":"The Medical Xchange","provider_url":"https:\/\/themedicalxchange.com\/en\/","title":"Chapter 3: Severe Eosinophilic Asthma: A Clinical Profile - The Medical Xchange","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"33O6ChFaVE\"><a href=\"https:\/\/themedicalxchange.com\/en\/review\/chapter-3-severe-eosinophilic-asthma-a-clinical-profile\/\">Chapter 3: Severe Eosinophilic Asthma: A Clinical Profile<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/themedicalxchange.com\/en\/review\/chapter-3-severe-eosinophilic-asthma-a-clinical-profile\/embed\/#?secret=33O6ChFaVE\" width=\"600\" height=\"338\" title=\"&#8220;Chapter 3: Severe Eosinophilic Asthma: A Clinical Profile&#8221; &#8212; The Medical Xchange\" data-secret=\"33O6ChFaVE\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/themedicalxchange.com\/wp-includes\/js\/wp-embed.min.js\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2017\/12\/MXCS-2509_severe_asthma_EN_Chap3_Table1.png","thumbnail_width":960,"thumbnail_height":720,"description":"Eosinophilic asthma has been validated as a clinically relevant phenotype at least in part by the clinical benefit derived from therapies that limit eosinophil activity. Biologics developed for this purpose are currently reserved for patients with severe asthma, a population that by definition is not adequately controlled on standard therapies. As a biomarker for use of biologics in eosinophilic asthma, eosinophilia is a prerequisite, but it is an imperfect predictor of benefit. As asthma is a complex and heterogeneous process, additional biomarkers may further define the patients most likely to respond to agents that downregulate the activity of this pro-inflammatory cell. In the diagnosis and treatment of severe eosinophilic asthma as it is currently defined, treatment with a biologic should be undertaken within a framework of expected benefit, safety and cost. Strategies for patient selection are likely to evolve as additional clinical data become available."}