{"version":"1.0","provider_name":"The Medical Xchange","provider_url":"https:\/\/themedicalxchange.com\/en\/","title":"Chapter 2: Hyaluronic Acid in the Knee: History, Characteristics and Efficacy - The Medical Xchange","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"etUOTF3HNT\"><a href=\"https:\/\/themedicalxchange.com\/en\/review\/solving-osteoarthritis-pain-control-current-stat-2\/\">Chapter 2: Hyaluronic Acid in the Knee: History, Characteristics and Efficacy<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/themedicalxchange.com\/en\/review\/solving-osteoarthritis-pain-control-current-stat-2\/embed\/#?secret=etUOTF3HNT\" width=\"600\" height=\"338\" title=\"&#8220;Chapter 2: Hyaluronic Acid in the Knee: History, Characteristics and Efficacy&#8221; &#8212; The Medical Xchange\" data-secret=\"etUOTF3HNT\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/themedicalxchange.com\/wp-includes\/js\/wp-embed.min.js\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2014\/07\/2506_Knee_OA_Chap_2_EN_Fig_1.PNG","thumbnail_width":960,"thumbnail_height":720,"description":"In the knee, hyaluronic acid (HA), a naturally-occurring compound with viscoelastic properties, is credited with several physiologic functions associated with joint homeostasis. This includes a role in compression force distribution, tissue lubrication, and regulation of cellular activities.(1) In patients with osteoarthritis (OA) of the knee, a chronic degenerative process that adversely affects both cartilage and bone,(2) viscosupplementation with exogenously-produced formulations of HA has been available for more than 15 years. Direct comparisons between current products remain limited, but the distinctions between treatments are potentially important for clinical activity. These distinctions, which may influence onset and duration of pain relief as well as safety, include composition, molecular weight, and molecular activity. Consideration of the physiochemical properties of HA may also be relevant to the more challenging goal of slowing or preventing further joint deterioration."}