{"version":"1.0","provider_name":"The Medical Xchange","provider_url":"https:\/\/themedicalxchange.com\/en\/","title":"Chapter 3: GERD - The Era of PPIs - The Medical Xchange","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"i0LVbM76VV\"><a href=\"https:\/\/themedicalxchange.com\/en\/review\/unmet-needs-in-ppi-therapy-for-gerd\/\">Chapter 3: GERD &#8211;&nbsp;The Era of PPIs<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/themedicalxchange.com\/en\/review\/unmet-needs-in-ppi-therapy-for-gerd\/embed\/#?secret=i0LVbM76VV\" width=\"600\" height=\"338\" title=\"&#8220;Chapter 3: GERD &#8211;&nbsp;The Era of PPIs&#8221; &#8212; The Medical Xchange\" data-secret=\"i0LVbM76VV\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/themedicalxchange.com\/wp-includes\/js\/wp-embed.min.js\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2011\/12\/Picture11__.png","thumbnail_width":1502,"thumbnail_height":1127,"description":"Proton pump inhibitors (PPIs) replaced previous options for the treatment of gastroesophageal reflux disease (GERD) because of superior acid control, a fundamental component of GERD pathophysiology. However, despite the high rates with which PPIs heal esophagitis, it is now well recognized that a substantial proportion of individuals do not achieve complete or even adequate relief of symptoms. Alternative strategies to improve symptom control which interferes with a patient&rsquo;s quality or life include high dose or twice-daily PPIs, newer delivery methods to improve pharmacologic effect over each dosing interval and the introduction of adjunctive treatments, including lifestyle modifications, to augment PPI activity. Pharmacologic targets other than acid control are being pursued but have not yet yielded marketable alternatives. Clinicians need to develop an awareness of the frequency with which patients on conventional PPI treatment are dissatisfied with treatment in order to consider strategies that may be effective for improving quality of life."}