{"version":"1.0","provider_name":"The Medical Xchange","provider_url":"https:\/\/themedicalxchange.com\/en\/","title":"Chapter 1: GERD - Current Challenges in Control - The Medical Xchange","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"R8Kd1TDjnv\"><a href=\"https:\/\/themedicalxchange.com\/en\/review\/unmet-needs-in-ppi-therapy-for-gerd-3\/\">Chapter 1: GERD &#8211;&nbsp;Current Challenges in Control<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/themedicalxchange.com\/en\/review\/unmet-needs-in-ppi-therapy-for-gerd-3\/embed\/#?secret=R8Kd1TDjnv\" width=\"600\" height=\"338\" title=\"&#8220;Chapter 1: GERD &#8211;&nbsp;Current Challenges in Control&#8221; &#8212; The Medical Xchange\" data-secret=\"R8Kd1TDjnv\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script type=\"text\/javascript\">\n\/* <![CDATA[ *\/\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/themedicalxchange.com\/wp-includes\/js\/wp-embed.min.js\n\/* ]]> *\/\n<\/script>\n","thumbnail_url":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2011\/10\/Picture1____.png","thumbnail_width":1502,"thumbnail_height":1127,"description":"The reasons that patients with gastroesophageal reflux disease (GERD) fail to achieve adequate symptom relief with proton pump inhibitors (PPIs) have proven surprisingly complex. While high rates of healing are achieved in patients with erosive esophagitis on conventional once-daily doses of PPIs, the proportion of patients with persistent symptoms despite healing is substantial. Relative to those with esophagitis, the proportion of patients with inadequate symptom control is even higher in patients with endoscopy-negative GERD (NERD). The large body of research exploring the relationship of acid- and non-acid reflux to symptoms of GERD has expanded the understanding of pathophysiological mechanisms. Insights from this research are guiding strategies with the potential to address deficiencies of current therapies. In essence, GERD has proven to be a heterogeneous entity with contributing etiological factors not limited to excess gastric acid secretion. A systematic approach toward understanding the key mechanisms of symptom genesis may improve treatment success."}