La pr\u00e9vention du cancer ou de l\u2019\u00e9volution de cette maladie chez les personnes qui y sont particuli\u00e8rement expos\u00e9es, voire dans l\u2019ensemble de la population, au moyen de l\u2019administration de m\u00e9dicaments ou de la consommation de divers aliments ou substances phytochimiques suscite de plus en plus d\u2019int\u00e9r\u00eat.<\/p>\n
Se consacrant \u00e0 cette avenue de recherche, des chercheurs se penchent tout particuli\u00e8rement sur le r\u00f4le de l\u2019inflammation dans l\u2019apparition du cancer. Ils tentent notamment de d\u00e9brouiller les nombreux m\u00e9canismes qui font probablement en sorte que l\u2019inflammation favorise la formation des tumeurs ou leur persistance, et de voir si les m\u00e9dicaments connus pour att\u00e9nuer l\u2019inflammation pourraient aussi r\u00e9duire le risque de cancer. Par exemple, de nombreuses \u00e9tudes ont d\u00e9montr\u00e9 que l\u2019acide ac\u00e9tylsalicylique (Aspirin\u00ae) et d\u2019autres antiinflammatoires non st\u00e9ro\u00efdiens (AINS) pouvaient r\u00e9duire le risque de cancer colorectal et peut-\u00eatre d\u2019autres types de cancer aussi. Il n\u2019en demeure pas moins qu\u2019il faudra pousser la recherche sur la s\u00e9lection des patients et la posologie optimale. Certains des bienfaits exerc\u00e9s \u00e0 ce chapitre par les statines pourraient aussi s\u2019expliquer par l\u2019activit\u00e9 anti-inflammatoire de ces m\u00e9dicaments.<\/p>\n
La chimiopr\u00e9vention des tumeurs c\u00e9r\u00e9brales d\u00e9vastatrices \u00e0 l\u2019aide de m\u00e9dicaments dot\u00e9s de propri\u00e9t\u00e9s anti-inflammatoires ou immunomodulatrices pourrait \u00eatre possible.<\/p><\/blockquote>\n
Il est ressorti d\u2019une \u00e9tude cas-t\u00e9moin que la chimiopr\u00e9vention de tumeurs c\u00e9r\u00e9brales d\u00e9vastatrices \u00e0 l\u2019aide de m\u00e9dicaments dot\u00e9s de propri\u00e9t\u00e9s anti-inflammatoires ou immuno-modulatrices pourrait \u00eatre possible. Cette \u00e9tude pilote, dont les r\u00e9sultats ont \u00e9t\u00e9 pr\u00e9sent\u00e9s lors de la r\u00e9union de la SNO de cette ann\u00e9e, a \u00e9t\u00e9 r\u00e9alis\u00e9e par la Dre Rose Lai et ses coll\u00e8gues de l\u2019Universit\u00e9 Columbia, \u00e0 New York, et de l\u2019Universit\u00e9 de Californie, \u00e0 San Francisco.<\/p>\n
Apr\u00e8s avoir \u00e9valu\u00e9 200 cas et 400 t\u00e9moins, ces chercheurs en sont venus \u00e0 la conclusion que la prise d\u2019une statine pendant plus de 6 mois r\u00e9duit le risque de gliome malin de 20 % (RRA = 0,8; IC \u00e0 95 % : de 0,6 \u00e0 1,1). La simvastatine, qui traverse plus facilement la barri\u00e8re h\u00e9mato-enc\u00e9phalique que les autres statines, a produit l\u2019effet le plus notable. \u00c0 preuve, elle a entra\u00een\u00e9 une baisse du risque significative de 50 % (RRA = 0,5; IC \u00e0 95 % : de 0,3 \u00e0 0,8). La prolongation de l\u2019utilisation de ce produit s\u2019est traduite par un effet protecteur encore plus marqu\u00e9 (analyse des tendances : p < 0,01).<\/p>\n
Lors d\u2019une \u00e9tude diff\u00e9rente, quoiqu\u2019apparent\u00e9e, les chercheurs ont constat\u00e9 que l\u2019emploi d\u2019AINS pendant plus de 6 mois avait diminu\u00e9 le risque de gliome de 50 % (RRA = 0,5; IC \u00e0 95 % : de 0,4 \u00e0 0,7).<\/p>\n
Prochaines \u00e9tapes<\/h2>\n
De nouveaux travaux de recherche s\u2019imposent pour confirmer ces observations et d\u00e9terminer comment ces m\u00e9dicaments exercent leurs effets chimiopr\u00e9ventifs et quels sont les sujets susceptibles de tirer avantage de leur utilisation. La Dre Lai et ses collaborateurs projettent de v\u00e9rifier si le polymorphisme g\u00e9n\u00e9tique des g\u00e8nes codant pour la voie HMG-CoA r\u00e9ductase, la Rho GTPase et la Ras GTPase, pourrait \u00eatre un facteur modificateur en mati\u00e8re de traitements par les statines. Au final, leurs travaux permettront peut-\u00eatre de s\u00e9lectionner les sujets ayant le bilan g\u00e9n\u00e9tique qui fera d\u2019eux de bons candidats pour la chimiopr\u00e9vention.<\/p>\n","protected":false},"excerpt":{"rendered":"
Montr\u00e9al <\/b> \u2013 La notion de chimiopr\u00e9vention laisse entendre que l\u2019administration de m\u00e9dicaments ou la consommation de certains aliments ou substances phytochimiques pourraient permettre de pr\u00e9venir le cancer ou d\u2019en emp\u00eacher l\u2019\u00e9volution. Or une \u00e9tude prim\u00e9e lors de la r\u00e9union de la SNO de cette ann\u00e9e a r\u00e9v\u00e9l\u00e9 qu\u2019il pourrait \u00eatre possible de pr\u00e9venir les tumeurs c\u00e9r\u00e9brales gr\u00e2ce aux statines et aux AINS.<\/p>\n","protected":false},"author":1,"featured_media":6500,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"tags":[407,287,662,286,448],"class_list":["post-3585","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","tag-2010-fr","tag-neurologie","tag-neurology-fr","tag-oncologie","tag-sno-fr","area_tag-neurologie","area_tag-oncologie"],"acf":[],"yoast_head":"\n
Les agents anti-inflammatoires pourraient r\u00e9duire le risque de gliomes - The Medical Xchange<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/themedicalxchange.com\/fr\/2010\/11\/18\/15e-reunion-scientifique-annuelle-de-la-society-fo\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les agents anti-inflammatoires pourraient r\u00e9duire le risque de gliomes - The Medical Xchange\" \/>\n<meta property=\"og:description\" content=\"Montr\u00e9al \u2013 La notion de chimiopr\u00e9vention laisse entendre que l\u2019administration de m\u00e9dicaments ou la consommation de certains aliments ou substances phytochimiques pourraient permettre de pr\u00e9venir le cancer ou d\u2019en emp\u00eacher l\u2019\u00e9volution. 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