{"id":5077,"date":"2013-06-05T12:09:28","date_gmt":"2013-06-05T16:09:28","guid":{"rendered":"https:\/\/themedicalxchange.com\/2013\/06\/05\/conference-internationale-de-2013-de-lamerican-tho\/"},"modified":"2022-02-03T11:57:18","modified_gmt":"2022-02-03T16:57:18","slug":"conference-internationale-de-2013-de-lamerican-tho","status":"publish","type":"post","link":"https:\/\/themedicalxchange.com\/fr\/2013\/06\/05\/conference-internationale-de-2013-de-lamerican-tho\/","title":{"rendered":"Syst\u00e8mes de lib\u00e9ration issus du g\u00e9nie particulaire : syst\u00e8mes d\u2019administration pour les antibiotiques oppos\u00e9s aux pneumopathies"},"content":{"rendered":"

Deux \u00e9tudes ont port\u00e9 sur l\u2019administration d\u2019antibiotiques \u00e0 des patients atteints d\u2019une pneumopathie chronique au moyen du m\u00eame dispositif mettant \u00e0 profit la technologie PulmoSphereMD<\/sup>. Par sa conception, ce syst\u00e8me permet d\u2019optimiser la taille et le poids des particules \u00e0 la lumi\u00e8re des lois de l\u2019a\u00e9rodynamique appliqu\u00e9e \u00e0 l\u2019inhalation afin d\u2019am\u00e9liorer la dispersion de l\u2019antibiotique en poudre s\u00e8che. Cette technologie repose sur la dessiccation d\u2019une \u00e9mulsion par atomisation, ce qui permet d\u2019obtenir des particules l\u00e9g\u00e8res et poreuses (Fig. 1)<\/a>. Les \u00e9tudes pr\u00e9sent\u00e9es dans ce rapport portent \u00e0 croire que cette nouvelle technologie permettrait d\u2019administrer localement des antibiotiques dot\u00e9s d\u2019une efficacit\u00e9 similaire, voire sup\u00e9rieure, \u00e0 celle des antibiotiques administr\u00e9s \u00e0 l\u2019aide de n\u00e9buliseurs, qu\u2019elle est d\u2019ailleurs appel\u00e9e \u00e0 supplanter vu sa plus grande commodit\u00e9. L\u2019\u00e9tude men\u00e9e sur l\u2019utilisation de la tobramycine contre la fibrose kystique (FK) est la plus importante des deux. Soixante-deux enfants atteints de cette maladie et que l\u2019on savait aux prises avec une infection \u00e0 Pseudomonas aeruginosa<\/em> ont \u00e9t\u00e9 r\u00e9partis al\u00e9atoirement de fa\u00e7on \u00e0 prendre par inhalation soit de la tobramycine soit un placebo. Or les chercheurs ont constat\u00e9 chez les enfants trait\u00e9s par la tobramycine des diff\u00e9rences extr\u00eamement significatives pour ce qui est de la charge bact\u00e9rienne des expectorations (p\u00a0<\/em>=\u00a00,002) et des am\u00e9liorations de la fonction respiratoire (p\u00a0<\/em><\u00a00,001) comparativement aux t\u00e9moins. \u00ab\u00a0L\u2019\u00e9tude principale visait essentiellement \u00e0 \u00e9valuer l\u2019efficacit\u00e9 de la tobramycine d\u2019apr\u00e8s la variation relative du pourcentage du VEMS th\u00e9orique entre le d\u00e9but et le 29e\u00a0<\/sup>jour de l\u2019\u00e9tude\u00a0\u00bb, a expliqu\u00e9 la Dre<\/sup>\u00a0Ivanka\u00a0Galeva, de l\u2019h\u00f4pital Alexandrovska, de Sofia, en Bulgarie, et auteure principale de l\u2019essai EDIT (Establish Tobramycin Dry Powder Efficacy Trial<\/em>). Selon la Dre<\/sup>\u00a0Galeva, l\u2019augmentation significative du VEMS observ\u00e9e au 29e<\/sup>\u00a0jour s\u2019est maintenue durant l\u2019\u00e9tude de prolongation qui comptait trois cycles suppl\u00e9mentaires de traitement (28\u00a0jours de traitement suivis d\u2019une fen\u00eatre th\u00e9rapeutique de 28\u00a0jours). Cette p\u00e9riode de prolongation a permis de d\u00e9montrer la suppression soutenue de P.\u00a0aeruginosa<\/em> et de dresser un bilan d\u2019effets ind\u00e9sirables acceptable. Les chercheurs ont jug\u00e9 que les effets ind\u00e9sirables graves rapport\u00e9s durant l\u2019\u00e9tude n\u2019avaient aucun lien avec le m\u00e9dicament exp\u00e9rimental. Une \u00e9quipe d\u2019investigateurs de divers \u00e9tablissements allemands ont d\u00e9clar\u00e9 qu\u2019au cours de la phase\u00a01 de l\u2019\u00e9tude sur la maladie pulmonaire obstructive chronique (MPOC), \u00ab\u00a0les donn\u00e9es tir\u00e9es des examens scintigraphiques ont montr\u00e9 que la poudre s\u00e8che de ciprofloxacine pour inhalation s\u2019\u00e9tait tr\u00e8s bien d\u00e9pos\u00e9e dans les poumons et de fa\u00e7on reproductible\u00a0\u00bb. Dans le cadre de cette \u00e9tude, 6\u00a0patients atteints de MPOC, 6\u00a0patients pr\u00e9sentant une bronchectasie n\u2019ayant pas la fibrose kystique pour cause et 12\u00a0volontaires sains ont \u00e9t\u00e9 \u00e9valu\u00e9s apr\u00e8s avoir inhal\u00e9 de la poudre s\u00e8che de ciprofloxacine radiomarqu\u00e9e. En fait, le d\u00e9p\u00f4t de m\u00e9dicament dans les zones pulmonaires p\u00e9riph\u00e9riques \u00e9tait plus prononc\u00e9 chez les patients atteints de MPOC ou de bronchectasie n\u2019ayant pas la fibrose kystique pour cause que chez les volontaires sains. Ce qu\u2019il importe toutefois de retenir, c\u2019est la biodisponibilit\u00e9 encourageante de la ciprofloxacine, des concentrations qui, logiquement, devraient exercer une forte activit\u00e9 antibiotique ayant effectivement \u00e9t\u00e9 mesur\u00e9es. Des essais fond\u00e9s sur des param\u00e8tres cliniques sont projet\u00e9s. Le g\u00e9nie particulaire s\u2019est consid\u00e9rablement perfectionn\u00e9. La meilleure compr\u00e9hension que les scientifiques ont acquise de la taille des particules en ce qui concerne l\u2019a\u00e9rodynamique appliqu\u00e9e \u00e0 l\u2019inhalation a eu un retentissement majeur sur la mise au point de la technologie PulmoSphereMD<\/sup>, de m\u00eame que sur celle des autres syst\u00e8mes con\u00e7us pour envoyer des agents \u00e0 action locale dans les tissus pulmonaires.<\/p>\n","protected":false},"excerpt":{"rendered":"

Philadelphie <\/b> \u2013 Selon des essais cliniques distincts pr\u00e9sent\u00e9s cette ann\u00e9e lors de la conf\u00e9rence internationale de l\u2019American Thoracic Society (ATS), les techniques de g\u00e9nie particulaire font de grands progr\u00e8s dans le domaine de l\u2019administration locale d\u2019antibiotiques oppos\u00e9s aux pneumopathies chroniques. L\u2019une de ces \u00e9tudes visait \u00e0 \u00e9valuer l\u2019efficacit\u00e9 et l\u2019innocuit\u00e9 de la tobramycine administr\u00e9e sous forme de poudre s\u00e8che dans les poumons d\u2019enfants atteints de fibrose kystique (FK). L\u2019autre \u00e9tude a servi \u00e0 mesurer le d\u00e9p\u00f4t de ciprofloxacine administr\u00e9e sous forme de poudre s\u00e8che pour inhalation dans les poumons d\u2019adultes atteints de maladie pulmonaire obstructive chronique (MPOC). Les r\u00e9sultats de ces deux \u00e9tudes donnent \u00e0 penser que cette technologie est s\u00fbre et extr\u00eamement efficace pour obtenir dans les tissus pulmonaires des concentrations th\u00e9rapeutiques d\u2019antibiotiques topiques. <\/p>\n","protected":false},"author":1,"featured_media":5078,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"tags":[369,423,523,477,361],"class_list":["post-5077","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","tag-369","tag-ats-fr","tag-extract-fr","tag-mpoc","tag-pneumologie","area_tag-pneumologie"],"acf":[],"yoast_head":"\nSyst\u00e8mes de lib\u00e9ration issus du g\u00e9nie particulaire : syst\u00e8mes d\u2019administration pour les antibiotiques oppos\u00e9s aux pneumopathies - The Medical Xchange<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/themedicalxchange.com\/fr\/2013\/06\/05\/conference-internationale-de-2013-de-lamerican-tho\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Syst\u00e8mes de lib\u00e9ration issus du g\u00e9nie particulaire : syst\u00e8mes d\u2019administration pour les antibiotiques oppos\u00e9s aux pneumopathies - The Medical Xchange\" \/>\n<meta property=\"og:description\" content=\"Philadelphie \u2013 Selon des essais cliniques distincts pr\u00e9sent\u00e9s cette ann\u00e9e lors de la conf\u00e9rence internationale de l\u2019American Thoracic Society (ATS), les techniques de g\u00e9nie particulaire font de grands progr\u00e8s dans le domaine de l\u2019administration locale d\u2019antibiotiques oppos\u00e9s aux pneumopathies chroniques. L\u2019une de ces \u00e9tudes visait \u00e0 \u00e9valuer l\u2019efficacit\u00e9 et l\u2019innocuit\u00e9 de la tobramycine administr\u00e9e sous forme de poudre s\u00e8che dans les poumons d\u2019enfants atteints de fibrose kystique (FK). L\u2019autre \u00e9tude a servi \u00e0 mesurer le d\u00e9p\u00f4t de ciprofloxacine administr\u00e9e sous forme de poudre s\u00e8che pour inhalation dans les poumons d\u2019adultes atteints de maladie pulmonaire obstructive chronique (MPOC). Les r\u00e9sultats de ces deux \u00e9tudes donnent \u00e0 penser que cette technologie est s\u00fbre et extr\u00eamement efficace pour obtenir dans les tissus pulmonaires des concentrations th\u00e9rapeutiques d\u2019antibiotiques topiques.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/themedicalxchange.com\/fr\/2013\/06\/05\/conference-internationale-de-2013-de-lamerican-tho\/\" \/>\n<meta property=\"og:site_name\" content=\"The Medical Xchange\" \/>\n<meta property=\"article:published_time\" content=\"2013-06-05T16:09:28+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-02-03T16:57:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2013\/06\/ATS_7006_Figure1_fr.PNG\" \/>\n\t<meta property=\"og:image:width\" content=\"960\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"nuagelab\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"nuagelab\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/fr\\\/2013\\\/06\\\/05\\\/conference-internationale-de-2013-de-lamerican-tho\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/fr\\\/2013\\\/06\\\/05\\\/conference-internationale-de-2013-de-lamerican-tho\\\/\"},\"author\":{\"name\":\"nuagelab\",\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/en\\\/#\\\/schema\\\/person\\\/c4e17cbf7de41a40b9366989481cfc4b\"},\"headline\":\"Syst\u00e8mes de lib\u00e9ration issus du g\u00e9nie particulaire : syst\u00e8mes d\u2019administration pour les antibiotiques oppos\u00e9s aux pneumopathies\",\"datePublished\":\"2013-06-05T16:09:28+00:00\",\"dateModified\":\"2022-02-03T16:57:18+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/fr\\\/2013\\\/06\\\/05\\\/conference-internationale-de-2013-de-lamerican-tho\\\/\"},\"wordCount\":685,\"image\":{\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/fr\\\/2013\\\/06\\\/05\\\/conference-internationale-de-2013-de-lamerican-tho\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/themedicalxchange.com\\\/wp-content\\\/uploads\\\/2013\\\/06\\\/ATS_7006_Figure1_fr.PNG\",\"keywords\":[\"2013\",\"ATS\",\"extract\",\"MPOC\",\"pneumologie\"],\"articleSection\":[\"Non classifi\u00e9(e)\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/fr\\\/2013\\\/06\\\/05\\\/conference-internationale-de-2013-de-lamerican-tho\\\/\",\"url\":\"https:\\\/\\\/themedicalxchange.com\\\/fr\\\/2013\\\/06\\\/05\\\/conference-internationale-de-2013-de-lamerican-tho\\\/\",\"name\":\"Syst\u00e8mes de lib\u00e9ration issus du g\u00e9nie particulaire : syst\u00e8mes d\u2019administration pour les antibiotiques oppos\u00e9s aux pneumopathies - 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L\u2019une de ces \u00e9tudes visait \u00e0 \u00e9valuer l\u2019efficacit\u00e9 et l\u2019innocuit\u00e9 de la tobramycine administr\u00e9e sous forme de poudre s\u00e8che dans les poumons d\u2019enfants atteints de fibrose kystique (FK). L\u2019autre \u00e9tude a servi \u00e0 mesurer le d\u00e9p\u00f4t de ciprofloxacine administr\u00e9e sous forme de poudre s\u00e8che pour inhalation dans les poumons d\u2019adultes atteints de maladie pulmonaire obstructive chronique (MPOC). Les r\u00e9sultats de ces deux \u00e9tudes donnent \u00e0 penser que cette technologie est s\u00fbre et extr\u00eamement efficace pour obtenir dans les tissus pulmonaires des concentrations th\u00e9rapeutiques d\u2019antibiotiques topiques.","og_url":"https:\/\/themedicalxchange.com\/fr\/2013\/06\/05\/conference-internationale-de-2013-de-lamerican-tho\/","og_site_name":"The Medical Xchange","article_published_time":"2013-06-05T16:09:28+00:00","article_modified_time":"2022-02-03T16:57:18+00:00","og_image":[{"width":960,"height":720,"url":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2013\/06\/ATS_7006_Figure1_fr.PNG","type":"image\/png"}],"author":"nuagelab","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"nuagelab","Dur\u00e9e de lecture estim\u00e9e":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/themedicalxchange.com\/fr\/2013\/06\/05\/conference-internationale-de-2013-de-lamerican-tho\/#article","isPartOf":{"@id":"https:\/\/themedicalxchange.com\/fr\/2013\/06\/05\/conference-internationale-de-2013-de-lamerican-tho\/"},"author":{"name":"nuagelab","@id":"https:\/\/themedicalxchange.com\/en\/#\/schema\/person\/c4e17cbf7de41a40b9366989481cfc4b"},"headline":"Syst\u00e8mes de lib\u00e9ration issus du g\u00e9nie particulaire : syst\u00e8mes d\u2019administration pour les antibiotiques oppos\u00e9s aux pneumopathies","datePublished":"2013-06-05T16:09:28+00:00","dateModified":"2022-02-03T16:57:18+00:00","mainEntityOfPage":{"@id":"https:\/\/themedicalxchange.com\/fr\/2013\/06\/05\/conference-internationale-de-2013-de-lamerican-tho\/"},"wordCount":685,"image":{"@id":"https:\/\/themedicalxchange.com\/fr\/2013\/06\/05\/conference-internationale-de-2013-de-lamerican-tho\/#primaryimage"},"thumbnailUrl":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2013\/06\/ATS_7006_Figure1_fr.PNG","keywords":["2013","ATS","extract","MPOC","pneumologie"],"articleSection":["Non classifi\u00e9(e)"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/themedicalxchange.com\/fr\/2013\/06\/05\/conference-internationale-de-2013-de-lamerican-tho\/","url":"https:\/\/themedicalxchange.com\/fr\/2013\/06\/05\/conference-internationale-de-2013-de-lamerican-tho\/","name":"Syst\u00e8mes de lib\u00e9ration issus du g\u00e9nie particulaire : syst\u00e8mes d\u2019administration pour les antibiotiques oppos\u00e9s aux pneumopathies - 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