{"id":6947,"date":"2017-09-18T10:44:09","date_gmt":"2017-09-18T14:44:09","guid":{"rendered":"https:\/\/themedicalxchange.com\/?p=6947\/"},"modified":"2021-07-20T10:07:00","modified_gmt":"2021-07-20T14:07:00","slug":"letude-cantos-fait-progresser-lhypothese-sur-linflammation-et-les-coronaropathies","status":"publish","type":"post","link":"https:\/\/themedicalxchange.com\/fr\/2017\/09\/18\/letude-cantos-fait-progresser-lhypothese-sur-linflammation-et-les-coronaropathies\/","title":{"rendered":"L\u2019\u00e9tude CANTOS fait progresser l\u2019hypoth\u00e8se sur l\u2019inflammation et les coronaropathies"},"content":{"rendered":"<h2>Un traitement anti-inflammatoire cardioprotecteur<\/h2>\n<p>\u00ab\u00a0Ces observations sont l\u2019aboutissement de plus de deux d\u00e9cennies de recherches entreprises apr\u00e8s que l\u2019on ait constat\u00e9 que la moiti\u00e9 des crises cardiaques se produisent chez des personnes qui ne font pas d\u2019hypercholest\u00e9rol\u00e9mie\u00a0\u00bb, a affirm\u00e9 le D<sup>r<\/sup>\u00a0Paul M.\u00a0Ridker, chercheur principal de l\u2019\u00e9tude CANTOS et Directeur du Centre de pr\u00e9vention des maladies cardiovasculaires de l\u2019H\u00f4pital Brigham and Women, de Boston, au Massachusetts. Les donn\u00e9es tir\u00e9es de cette \u00e9tude ont \u00e9t\u00e9 pr\u00e9sent\u00e9es sous forme de r\u00e9sum\u00e9 de derni\u00e8re minute dans le cadre du congr\u00e8s de la SEC de cette ann\u00e9e et publi\u00e9es simultan\u00e9ment dans le <em>New England Journal of Medicine<\/em> (RIDKER, P. M., <em>et\u00a0al.<\/em> <em>N Engl J Med <\/em>2017; 17\u00a0ao\u00fbt, diffus\u00e9 en ligne avant impression).<\/p>\n<p>Lors de l\u2019\u00e9tude CANTOS, 10 061 patients ayant d\u00e9j\u00e0 subi un IM et dont la concentration de prot\u00e9ine C-r\u00e9active dos\u00e9e par une m\u00e9thode ultrasensible (hs-CRP) s\u2019\u00e9levait \u00e0 2 mg\/L ou plus ont \u00e9t\u00e9 r\u00e9partis al\u00e9atoirement de fa\u00e7on \u00e0 recevoir tous les 3 mois une des 3 doses de canakinumab (un anticorps monoclonal) ou le placebo par voie sous-cutan\u00e9e. Le canakinumab, qui est homologu\u00e9 dans de nombreux pays pour le traitement de troubles rhumatologiques, cible l\u2019IL-1\u03b2, une cytokine jouant un r\u00f4le pr\u00e9pond\u00e9rant dans l\u2019inflammation. Au moment de leur recrutement, 97 % des patients \u00e9taient trait\u00e9s par des statines; leur concentration m\u00e9diane de C-LDL se chiffrait \u00e0 2,0 mmol\/L environ.<\/p>\n<p>Au terme d\u2019une p\u00e9riode de suivi m\u00e9diane de 3,7\u00a0ans, le rapport des risques instantan\u00e9s (RRI) calcul\u00e9 pour le canakinumab \u00e0 150\u00a0mg pour le param\u00e8tre d\u2019\u00e9valuation composite principal de l\u2019efficacit\u00e9 (IM non mortel, AVC non mortel et d\u00e9c\u00e8s d\u2019origine cardiovasculaire) a atteint le seuil la signification statistique ajust\u00e9 en fonction de la multiplicit\u00e9 comparativement au placebo (RRI\u00a0: 0,85; <em>p\u00a0<\/em>=\u00a00,021) (Figure\u00a01). Cette baisse de 15\u00a0% des incidents \u00e9tait similaire \u00e0 celle obtenue avec la dose la plus \u00e9lev\u00e9e, soit celle de 300\u00a0mg (RRI\u00a0: 0,86; <em>p\u00a0<\/em>=\u00a00,031). La baisse relative de 7\u00a0% des incidents enregistr\u00e9e avec la dose la plus faible (50\u00a0mg) n\u2019a pas franchi le seuil de la signification statistique (<em>p\u00a0<\/em>=\u00a00,3). Pour ce qui est de la dose de 150\u00a0mg, les chercheurs ont aussi not\u00e9 une baisse significative de 17\u00a0% d\u2019un param\u00e8tre d\u2019\u00e9valuation composite secondaire, qui comprenait entre autres l\u2019hospitalisation pour cause d\u2019angor instable commandant une intervention de revascularisation (<em>p\u00a0<\/em>=<em>\u00a0<\/em>0,005). \u00c0 48\u00a0mois, ils ont constat\u00e9 comparativement au placebo des baisses de la concentration de hs-CRP significatives et proportionnelles \u00e0 la dose de canakinumab, celles-ci atteignant 41\u00a0% avec la dose la plus forte.<\/p>\n<p>\u00c0 l\u2019instar d\u2019autres agents ciblant des cytokines inflammatoires, le canakinumab a \u00e9t\u00e9 reli\u00e9 \u00e0 une plus grande fr\u00e9quence des infections que le placebo, certaines ayant \u00e9t\u00e9 mortelles (0,31 vs 0,18; <em>p\u00a0<\/em>=\u00a00,02). En revanche, il a \u00e9t\u00e9 associ\u00e9 \u00e0 une fr\u00e9quence plus faible de cancers mortels (0,45 vs 0,64; <em>p\u00a0<\/em>=\u00a00,02) proportionnelle \u00e0 la dose et \u00e0 une fr\u00e9quence significativement plus basse d\u2019arthrite, de goutte et d\u2019arthrose. Il n\u2019y a eu aucune diff\u00e9rence significative entre le canakinumab et le placebo pour ce qui est des d\u00e9c\u00e8s toutes causes confondues. <a href=\"javascript:void(0)\" class=\"show-image\" data-index=\"0\">(Fig. 1)<\/a><\/p>\n<p>Selon le D<sup>r<\/sup>\u00a0Ridker, les r\u00e9sultats de l\u2019\u00e9tude CANTOS ouvrent un nouveau chapitre en cardiologie pr\u00e9ventive. Il a parl\u00e9 de la protection contre les incidents cardiovasculaires conf\u00e9r\u00e9e par la di\u00e8te et l\u2019exercice comme \u00e9tant la premi\u00e8re \u00e9tape et celle offerte par les traitements hypocholest\u00e9rol\u00e9miants comme la deuxi\u00e8me. Les donn\u00e9es issues de l\u2019\u00e9tude CANTOS, qui ont permis d\u2019\u00e9tablir un parall\u00e8le entre un traitement anti-inflammatoire et la cardioprotection, \u00ab\u00a0ouvrent la voie \u00e0 une troisi\u00e8me \u00e9tape\u00a0\u00bb.<\/p>\n<h2>Conclusion<\/h2>\n<p>Dans son \u00e9ditorial publi\u00e9 dans le <em>New England Journal<\/em> <em>of Medicine<\/em>, le D<sup>r<\/sup>\u00a0Robert Harrington, Pr\u00e9sident, du D\u00e9partement de m\u00e9decine de l\u2019Universit\u00e9 Stanford, en Californie, s\u2019est dit d\u2019accord dans une large mesure avec les conclusions de l\u2019\u00e9tude. Il a \u00e9crit\u00a0: \u00ab\u00a0L\u2019\u00e9tude CANTOS a permis de faire progresser l\u2019hypoth\u00e8se sur le lien entre l\u2019inflammation et les coronaropathies\u00a0\u00bb. Restant circonspect \u00e0 propos de l\u2019usage syst\u00e9matique du canakinumab ou d\u2019autres agents anti-inflammatoires d\u2019ici \u00e0 ce que nous en sachions plus sur leur efficacit\u00e9, leur innocuit\u00e9 et leur co\u00fbt, il a toutefois admis que ces donn\u00e9es sur un nouveau mode d\u2019action ont suscit\u00e9 \u00ab\u00a0un vif enthousiasme chez les scientifiques et les cliniciens\u00a0\u00bb.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><b> Barcelone <\/b> \u2013 Un traitement dirig\u00e9 contre une cytokine inflammatoire a permis de rar\u00e9fier significativement les incidents cardiovasculaires majeurs chez des patients ayant d\u00e9j\u00e0 subi un infarctus du myocarde (IM). Cet effet positif a \u00e9t\u00e9 mis au jour lors de l\u2019\u00e9tude CANTOS, une \u00e9tude multinationale men\u00e9e avec contr\u00f4le placebo et r\u00e9partition al\u00e9atoire de plus de 10 000 patients. Il en est ressorti que l\u2019inflammation est un acteur important dans les coronaropathies, un constat qui vient bouleverser les fondements conceptuels du processus pathologique de ces maladies et qui ouvre la voie \u00e0 une nouvelle option de traitement.<\/p>\n","protected":false},"author":9,"featured_media":6950,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"tags":[412,521,301,512,523,394],"class_list":["post-6947","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","tag-2017-fr","tag-2017-fr-2","tag-cardiologie","tag-esc-fr","tag-extract-fr","tag-sec","area_tag-cardiologie"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>L\u2019\u00e9tude CANTOS fait progresser l\u2019hypoth\u00e8se sur l\u2019inflammation et les coronaropathies - The Medical Xchange<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/themedicalxchange.com\/en\/2017\/09\/08\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"L\u2019\u00e9tude CANTOS fait progresser l\u2019hypoth\u00e8se sur l\u2019inflammation et les coronaropathies - The Medical Xchange\" \/>\n<meta property=\"og:description\" content=\"Barcelone \u2013 Un traitement dirig\u00e9 contre une cytokine inflammatoire a permis de rar\u00e9fier significativement les incidents cardiovasculaires majeurs chez des patients ayant d\u00e9j\u00e0 subi un infarctus du myocarde (IM). Cet effet positif a \u00e9t\u00e9 mis au jour lors de l\u2019\u00e9tude CANTOS, une \u00e9tude multinationale men\u00e9e avec contr\u00f4le placebo et r\u00e9partition al\u00e9atoire de plus de 10 000 patients. Il en est ressorti que l\u2019inflammation est un acteur important dans les coronaropathies, un constat qui vient bouleverser les fondements conceptuels du processus pathologique de ces maladies et qui ouvre la voie \u00e0 une nouvelle option de traitement.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/themedicalxchange.com\/en\/2017\/09\/08\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"The Medical Xchange\" \/>\n<meta property=\"article:published_time\" content=\"2017-09-18T14:44:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-07-20T14:07:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2017\/09\/EX-7014_ESC_fr_Fig1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"960\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Daniela Lopes\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Daniela Lopes\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/en\\\/2017\\\/09\\\/08\\\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/en\\\/2017\\\/09\\\/08\\\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\\\/\"},\"author\":{\"name\":\"Daniela Lopes\",\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/en\\\/#\\\/schema\\\/person\\\/f3318b53ccceaeb046bcb26e99f5c94c\"},\"headline\":\"L\u2019\u00e9tude CANTOS fait progresser l\u2019hypoth\u00e8se sur l\u2019inflammation et les coronaropathies\",\"datePublished\":\"2017-09-18T14:44:09+00:00\",\"dateModified\":\"2021-07-20T14:07:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/en\\\/2017\\\/09\\\/08\\\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\\\/\"},\"wordCount\":765,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/en\\\/2017\\\/09\\\/08\\\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/themedicalxchange.com\\\/wp-content\\\/uploads\\\/2017\\\/09\\\/EX-7014_ESC_fr_Fig1.png\",\"keywords\":[\"2017\",\"2017\",\"cardiologie\",\"ESC\",\"extract\",\"SEC\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/themedicalxchange.com\\\/en\\\/2017\\\/09\\\/08\\\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\\\/\",\"url\":\"https:\\\/\\\/themedicalxchange.com\\\/en\\\/2017\\\/09\\\/08\\\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\\\/\",\"name\":\"L\u2019\u00e9tude CANTOS fait progresser l\u2019hypoth\u00e8se sur l\u2019inflammation et les coronaropathies - 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Cet effet positif a \u00e9t\u00e9 mis au jour lors de l\u2019\u00e9tude CANTOS, une \u00e9tude multinationale men\u00e9e avec contr\u00f4le placebo et r\u00e9partition al\u00e9atoire de plus de 10 000 patients. Il en est ressorti que l\u2019inflammation est un acteur important dans les coronaropathies, un constat qui vient bouleverser les fondements conceptuels du processus pathologique de ces maladies et qui ouvre la voie \u00e0 une nouvelle option de traitement.","og_url":"https:\/\/themedicalxchange.com\/en\/2017\/09\/08\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\/","og_site_name":"The Medical Xchange","article_published_time":"2017-09-18T14:44:09+00:00","article_modified_time":"2021-07-20T14:07:00+00:00","og_image":[{"width":960,"height":720,"url":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2017\/09\/EX-7014_ESC_fr_Fig1.png","type":"image\/png"}],"author":"Daniela Lopes","twitter_card":"summary_large_image","twitter_misc":{"\u00c9crit par":"Daniela Lopes","Dur\u00e9e de lecture estim\u00e9e":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/themedicalxchange.com\/en\/2017\/09\/08\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\/#article","isPartOf":{"@id":"https:\/\/themedicalxchange.com\/en\/2017\/09\/08\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\/"},"author":{"name":"Daniela Lopes","@id":"https:\/\/themedicalxchange.com\/en\/#\/schema\/person\/f3318b53ccceaeb046bcb26e99f5c94c"},"headline":"L\u2019\u00e9tude CANTOS fait progresser l\u2019hypoth\u00e8se sur l\u2019inflammation et les coronaropathies","datePublished":"2017-09-18T14:44:09+00:00","dateModified":"2021-07-20T14:07:00+00:00","mainEntityOfPage":{"@id":"https:\/\/themedicalxchange.com\/en\/2017\/09\/08\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\/"},"wordCount":765,"commentCount":0,"image":{"@id":"https:\/\/themedicalxchange.com\/en\/2017\/09\/08\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/themedicalxchange.com\/wp-content\/uploads\/2017\/09\/EX-7014_ESC_fr_Fig1.png","keywords":["2017","2017","cardiologie","ESC","extract","SEC"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/themedicalxchange.com\/en\/2017\/09\/08\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\/","url":"https:\/\/themedicalxchange.com\/en\/2017\/09\/08\/cantos-trial-advances-inflammatory-hypothesis-of-coronary-artery-disease\/","name":"L\u2019\u00e9tude CANTOS fait progresser l\u2019hypoth\u00e8se sur l\u2019inflammation et les coronaropathies - 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