The Medical Xchange

  • Edit profile
  • Logout
Login    Register

Expert Review

13th European AIDS Clinical Society (EACS) Conference: Expert Review

HIV 2011

Protease Inhibitors in Nucs-Sparing Strategies: Report from the EACS

Dr. Patrice Junod
Clinique Médicale l’Actuel, Montreal, QC
Dr. M. John Gill
Southern Alberta HIV Clinic, Calgary, AB

Belgrade – Antiretroviral combinations that do not include nucleoside reverse transcriptase inhibitors (NRTIs; ‘nucs’), so-called nucs-sparing regimens, were once largely tested as a strategy to avoid mitochondrial toxicities. However, this approach now offers promise in reducing some of the specific age-related morbidities exacerbated by NRTIs, such as progressive renal impairment. It could also save costs. At the 13th European AIDS Clinical Society (EACS) meeting, a variety of new information was presented on the role of protease inhibitors (PIs) in nucs-sparing regimens. Whether combined with another PI or a drug from another class, such regimens were reported as already being in routine use at some centres even while clinical studies attempt to define which patients are the best candidates. Overall, the data presented suggested that nucs-sparing is a reasonable and appropriate option in at least some select patient groups for whom NRTIs are relatively contraindicated. As more data become available, this approach may beextended to the larger HIV population, including those who are treatment naive.

Show review


The information and opinions expressed herein are those of the participants and do not necessarily reflect those of Xfacto Communications Inc. or the sponsor. The distribution of this meeting report was made possible through industry support under written agreement that ensures editorial independence. The content is for educational purposes and should not be taken as an endorsement of any products, uses or doses. Physicians should consult the appropriate monograph before prescribing any drugs. Distribution, reproduction, alteration of this program is strictly prohibited without written consent of Xfacto Communications Inc. Copyright 2022. All rights reserved. The Medical XchangeTM

This web site is solely for healthcare professionals

Yes, I am a healthcare professional No, I am not a healthcare professional
New user?
Sign up for the Medical Xchange Here you'll find expert commentary from the most recent medical meetings around the world, as well as features and interviews with top healthcare professionals.
First name* Last name*
Title Gender*
Email* Confirm Email*
Password* Password must have at least 8 characters with at least one Capital letter, one lower case letter and one number or special character Confirm Password*
Profession* Speciality*
Country* Province*