The Medical Xchange

  • Edit profile
  • Logout
Login    Register

Expert Review

IAS 2011: Expert Review

HIV 2011

Protease Inhibitors after 15 Years: Report from the IAS

Dr. Jean-Guy Baril
Clinique Médicale du Quartier Latin, Montreal, QC
Dr. Jason Brunetta
Maple Leaf Medical Clinic, Toronto, ON

Rome – In 1996, a protease inhibitor (PI)-based antiretroviral combination led to the first opportunity for long-term survival for most patients living with human immunodeficiency virus (HIV). On the 15th anniversary of that breakthrough, PIs are no longer a mandatory component of an effective antiretroviral regimen, but they remain an important and reliable option in HIV control. As they are among the most potent antiretroviral agents, PIs remain a reasonable choice in a wide variety of clinical scenarios, including first-line treatment. Although some of the initially introduced PIs remain available, the common PIs in most formularies are ritonavir-boosted atazanavir (ATV/r), darunavir (DRV/r), and lopinavir (LPV/r). Relative to first generation PIs, these have few dosing restrictions, a low pill burden, and less relative risk of adverse events. Despite the broad experience with all of these agents, optimal use of PIs remains a dynamic exploration of relative strengths and weaknesses, particularly in the context of an aging HIV-infected population. This update assembles key studies on PIs from the 2011 IAS meeting.

Show review


The information and opinions expressed herein are those of the participants and do not necessarily reflect those of Xfacto Communications Inc. or the sponsor. The distribution of this meeting report was made possible through industry support under written agreement that ensures editorial independence. The content is for educational purposes and should not be taken as an endorsement of any products, uses or doses. Physicians should consult the appropriate monograph before prescribing any drugs. Distribution, reproduction, alteration of this program is strictly prohibited without written consent of Xfacto Communications Inc. Copyright 2022. All rights reserved. The Medical XchangeTM

This web site is solely for healthcare professionals

Yes, I am a healthcare professional No, I am not a healthcare professional
New user?
Sign up for the Medical Xchange Here you'll find expert commentary from the most recent medical meetings around the world, as well as features and interviews with top healthcare professionals.
First name* Last name*
Title Gender*
Email* Confirm Email*
Password* Password must have at least 8 characters with at least one Capital letter, one lower case letter and one number or special character Confirm Password*
Profession* Speciality*
Country* Province*